Patients with the following conditions should be careful in taking Phenylpropanolamine (PPA): High blood pressure, toxic goiter, benign prostatic hypertrophy, heart rate irregularity, glaucoma and if taking antidepressants. Antihistamines may cause drowsiness and dulling of mental alertness where loss of attentions may lead to accidents. This product may be given to pregnant and nursing women if benefit outweighs the risk.