Xacil Dosage/Direction for Use

Parenteral drug products should be inspected visually for particulate matter and discoloration, prior to administration whenever solution and container permit.
The recommended dosages are given as follows. In severe, stubborn infections, a higher dosage may be administered.
Adults: Intramuscular Use: 250 mg every 4-6 hours.
Intravenous Use: 500 mg every 4-6 hours, administered into a vein either directly or via a drip-tube over a period of 3-4 min.
More rapid administration may result inconvulsive seizures.
Infants and Children: In infants up to 2 years of age, one-quarter of the adult dosage.
In children 2-10 years of age, half the adult dosage.
Renal Insufficiency: In the presence of severe renal impairment (creatinine clearance <10 mL/min) a reduction in dose or extension of dose interval should be considered.
Instruction for Use: Reconstitution: For Intravenous doses (IV): 500 mg reconstitute with 4.8 mL WFI (to make 5.0 mL 100 mg/mL solution).
For Intramuscular doses (IM): 500 mg reconstitute with 1.7 mL WFI (to make 2.0 mL 250 mg/mL solution).
Further Dilution: IV Infusion: Dilute 1 vial to 125-250 mL diluent.
Continuous IV Infusion: Dose >500 mg can be diluted with 500 mL diluent.
Maximum concentration 2 mg/mL.
Administration & Infusion Rate: IM: Slow IV bolus injection: Administer the reconstituted solution over at least 3-5 minutes.
IV infusion: Administer over 60 minutes.
Continuous Infusion: Administer over 6-12 hours.
Compatible diluents for dilution: This product is compatible with the following infusion solutions: Sterile water for injection; 0.9% sodium chloride; 5% dextrose.
Route of Administration: The recommended route of administration is by intravenous and intramuscular injection.