Viartril-S Drug Interactions

No specific drug interaction studies have been performed. However, the physico-chemical and pharmacokinetic properties of glucosamine sulphate suggest a low potential for interactions. In addition, glucosamine sulphate was found not to inhibit or to induce any of the major human CYP450 enzymes. In fact, the compound does not compete for absorption mechanisms and, after absorption, does not bind to plasma proteins, while its metabolic fate as an endogenous substance incorporated in proteoglycans or degraded independently of the cytochrome enzyme system, is unlikely to give rise to drug interactions.
An increased effect of coumarinic anticoagulants during concomitant treatment with glucosamine sulphate has been reported. Therefore, a closer monitoring of the coagulation parameters may be considered in these patients when initiating or ending glucosamine therapy.
The oral administration of glucosamine sulphate can enhance the gastrointestinal absorption of tetracyclines but the clinical relevance of this interaction is probably limited.
Steroidal or non-steroidal analgesic or anti-inflammatory agents can be administered together with glucosamine sulphate.