Twinrix Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Per 1 mL Inactivated HAV 720 ELISA U adsorbed, recombinant HBsAg 20 mcg adsorbed

Indications/Uses

Non-immune adults, adolescents & childn from 1 yr at risk of both hepatitis A & B infection.

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Dosage/Direction for Use

IM Adult & adolescent ≥16 yr 3 primary doses at 0, 1, 6 mth (standard schedule) or 0, 7, 21 days followed by 4th dose at 12 mth (rapid schedule). Childn & adolescent 1-15 yr 2 primary doses at 0, 6-12 mth. Booster dose General guidelines can be drawn from experience w/ monovalent vaccines.

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Overdosage

View Twinrix overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity to vaccine, monovalent hepatitis A or B, neomycin or after previous inj.

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Special Precautions

Anaphylactic reactions. Not to be inj intravascularly. Not for prevention against infection caused by other agents eg, hepatitis C, E & other pathogens infecting the liver. Not recommended for post-exposure prophylaxis eg, needle-stick injury. Postpone vaccination in patients w/ acute severe febrile illness. Syncope. Haemodialysis or immunocompromised patients. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache; inj site pain & redness, fatigue. GI symptoms eg, diarrhoea, nausea, vomiting; inj site swelling. Adults & childn ≥16 yr: Inj site reaction, malaise. Childn 1-15 yr: Loss of appetite; irritability. Drowsiness; fever.

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Drug Interactions

Adequate response may not be achieved w/ immunosuppressants. Not to be mixed w/ other vaccines in same syringe.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Twinrix detailed prescribing information

Storage

View Twinrix storage conditions for details to ensure optimal shelf-life.

Description

View Twinrix description for details of the chemical structure and excipients (inactive components).

Action

View Twinrix mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Vaccines, Antisera & Immunologicals

ATC Classification

J07BC20 - combinations ; Belongs to the class of hepatitis viral vaccines.

Regulatory Classification

Presentation/Packing

Form

Twinrix vaccine susp for inj (pre-filled syringe) 1 mL

Packing/Price

1's

Twinrix

hepatitis a and hepatitis b vaccine

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig Pharma