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The drug should not be used during pregnancy unless clearly needed. It should not be used during late pregnancy due to its known effect on the human fetus.
Use of NSAIDs at about 20 weeks of gestation or later in pregnancy may cause foetal renal dysfunction leading to oligohydramnios and in some cases, neonatal renal impairment. These adverse outcomes are seen, on average, after days to weeks of treatment, although oligohydramnios has been infrequently reported as soon as 48 hours after NSAID initiation. Oligohydramnios is often, but not always, reversible with treatment discontinuation.
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