Sunprox Drug Interactions

Naproxen sodium may cause gastrointestinal bleeding and may inhibit platelet aggregation, thus, the drug should be used with caution in patients receiving anticoagulant or thrombolytic agents. The effects of naproxen sodium are substantially potentiated by concomitant administration of probenecid.
Concomitant administration of naproxen sodium and methotrexate can result in severe, sometimes fatal toxicity. Naproxen sodium also interacts with prednisolone, frusemide, and salicylates.
Lithium: Decreased clearance and increased serum concentration of lithium, resulting in toxicity on some occasions, have been reported.
Quinolone antibiotics: NSAIDs can increase the central adverse effects, leading to convulsions.
Protein-bound drugs: Because naproxen is highly protein bound, it theoretically could be displaced from binding sites by, or it could displace from binding sites, other protein-bound drugs, such as oral anticoagulants, hydantoins, salicylates, sulfonamides, and sulfonylureas.
Furosemide: The natriuretic effect of furosemide has been reported to be inhibited. It was suggested that NSAIDs should not be used during diuretic therapy for cardiac failure.
Beta-blockers: The antihypertensive effect of propranolol and other beta-blockers can be reduced.