Prostin E2 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Dinoprostone

Indications/Uses

Induction of labour especially in patients w/ favourable induction features.

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Dosage/Direction for Use

Initially, insert 1 tab (3 mg) high into posterior fornix. 2nd tab may be inserted after 6-8 hr if labor is not established. Max: 6 mg in 24 hr.

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Overdosage

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Contraindications

Hypersensitivity to dinoprostone or prostaglandins. History of caesarean section or major uterine surgery; cephalopelvic disproportion, foetal malpresentation is present; pre-existing foetal distress; history of difficult labour &/or traumatic delivery; unexplained vag discharge & bleeding &/or abnormal uterine bleeding; evidence of placenta praevia. Patients w/ pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.

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Special Precautions

Asthma or history of asthma, epilepsy or history of epilepsy, glaucoma or raised IOP, compromised CV, hepatic or renal function, HTN, ruptured chorioamniotic membranes; known history of hypertonic uterine contractility or tetanic uterine contractions; patients w/ multiple pregnancy. Monitor uterine activity, foetal heart rate & cervical dilation during therapy. Evaluate cephalopelvic relationships prior to use. Avoid contact w/ skin. Women ≥35 yr, w/ complications during pregnancy & gestational age >40 wk.

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Use In Pregnancy & Lactation

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Adverse Reactions

Hypersensitivity reactions; diarrhea, nausea, vomiting; back pain; uterine contractile abnormalities & rupture, abruptio placenta, pulmonary amniotic fluid embolism, rapid cervical dilatation; warm feeling in vag; fever; HTN; asthma, bronchospasm. Foetal & neonatal death, still births; fetal distress/altered fetal heart rate, neonatal distress/low Apgar score.

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Drug Interactions

Accentuated response w/ exogenous prostaglandin therapy. Not recommended in concurrent use w/ other oxytocic agents.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Prostin E2 detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Drugs Acting on the Uterus

ATC Classification

G02AD02 - dinoprostone ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.

Regulatory Classification

Presentation/Packing

Form

Prostin E2 vag tab 3 mg

Packing/Price

4's

Prostin E2

dinoprostone

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma