Noveron Drug Interactions

The following drugs have been shown to influence the magnitude and/or duration of action of non-depolarizing neuromuscular blocking agents: Effect of other drugs on Noveron: Increased effect: Halogenated volatile anesthetics potentiate the neuromuscular block of Noveron. The effect only becomes apparent with maintenance dosing. Reversal of the block with acetylcholinesterase inhibitors could also be inhibited.
After intubation with suxamethonium.
Long-term concomitant use of corticosteroids and Noveron in the ICU may result in prolonged duration of neuromuscular block or myopathy (see Precautions and Adverse Reactions).
Other drugs: Antibiotics: Aminoglycoside, lincosamide and polypeptide antibiotics, acylamino-penicillin antibiotics.
Diuretics, quinidine and its isomer quinine, magnesium salts, calcium channel blocking agents, lithium salts, local anesthetics (lidocaine i.v, bupivacaine epidural) and acute administration of phenytoin or β-blocking agents.
Recurarisation has been reported after post-operative administration of: aminoglycoside, lincosamide, polypeptide and acylamino-penicillin antibiotics, quinidine, quinine and magnesium salts (see Precautions).
Decreased effect: Prior chronic administration of phenytoin or carbamazepine.
Calcium chloride, potassium chloride.
Protease inhibitors (gabexate, ulinastatin).
Variable effect: Administration of other non-depolarizing neuromuscular blocking agents in combination with Noveron may produce attenuation or potentiation of the neuromuscular block, depending on the order of administration and the neuromuscular blocking agent used.
Suxamethonium given after the administration of Noveron may produce potentiation or attenuation of the neuromuscular blocking effect of Noveron.
Effect of Noveron on other drugs: Noveron combined with lidocaine may result in a quicker onset of action of lidocaine.
Paediatric population: No formal interaction studies have been performed. The mentioned interactions for adults and their special warnings and precautions for use should be taken into account for paediatric patients.