Noveron: Side Effects & Dosing

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Rocuronium Br

Indications/Uses

Adjunct to general anesth to facilitate endotracheal intubation, provide skeletal muscle relaxation & facilitate mechanical ventilation in adults, childn & infants from 1 mth. Adjunct in ICU to facilitate mechanical ventilation as part of Rapid Sequence Induction in adults.

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Dosage/Direction for Use

Surgical procedures Tracheal intubation: 0.6 mg/kg. Maintenance: 0.15 mg/kg. Long-term inhalation anaesth: Reduce to 0.075-0.1 mg/kg. Maintenance: Best given when twitch height has recovered to 25% of control twitch height. Continuous infusion: 0.6 mg/kg loading dose. Geriatric & patient w/ hepatic, biliary &/or renal failure 0.6 mg/kg. Maintenance: 0.075-0.1 mg/kg. Intensive care procedures Tracheal intubation: 0.6 mg/kg. Maintenance: 0.3-0.6 mg/kg during 1st hr, may be decreased during the next 6-12 hr.

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Overdosage

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Contraindications

Hypersensitivity to rocuronium or Br ion.

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Special Precautions

Hypersensitivity. Not recommended for facilitation of mechanical ventilation in intensive care of ped & geriatric patients. Conditions associated w/ prolonged circulation time eg, CV disease, oedematous state. Neuromuscular disease, poliomyelitis, myasthenia gravis or myasthenic (Eaton-Lambert) syndrome; hypothermia; obesity; burns; hypokalaemia, hypermagnesaemia, hypocalcaemia, hypoproteinaemia, dehydration, acidosis, hypercapnia, cachexia. Residual neuromuscular blockade. Long-term use. Ensure to correct severe electrolyte disturbances, altered blood pH or dehydration. Concomitant use w/ corticosteroids; suxamethonium. May affect ability to drive & use machines. Hepatic &/or biliary tract disease; renal failure. Pregnancy & lactation. Not recommended for facilitating tracheal intubation conditions during rapid sequence induction in ped patients. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Inj site pain/reaction, changes in vital signs, prolonged neuromuscular block. Anaphylactic & anaphylactoid reactions.

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Drug Interactions

Increased effects w/ halogenated volatile anesth, suxamethonium, corticosteroids; aminoglycoside, lincosamide, polypeptide & acylamino-penicillin antibiotics; diuretics, quinidine, quinine, Mg & lithium salts, Ca-channel blockers, local anesth (lidocaine IV, epidural bupivacaine), phenytoin or β-blockers. Recurarisation w/ aminoglycoside, lincosamide, polypeptide & acylamino-penicillin antibiotics, quinidine, quinine, Mg salts. Decreased effects w/ CaCl, KCl, phenytoin or carbamazepine; PIs eg, gabexate, ulinastatin. Potentiated or attenuated neuromuscular-blocking effects w/ other non-depolarizing neuromuscular blockers, suxamethonium. Quicker onset of lidocaine action.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Noveron detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Neuromuscular Blocking Agents

ATC Classification

M03AC09 - rocuronium bromide ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.

Regulatory Classification

Presentation/Packing

Form

Noveron soln for inj 10 mg/mL

Packing/Price

5 mL x 12 × 1's

Noveron

rocuronium bromide

Manufacturer:

Novell Pharma

Distributor:

Averroes Pharma