Most of the undesirable effects reported by the subjects occur during the early phase of treatment and are mainly dose dependent. Irritation in the mouth and throat may be experienced, however most subjects adapt to this with ongoing use. Allergic reactions (including symptoms of anaphylaxis) occur rarely during use of Nicorette chewing gum.
Like all medicines, Nicorette chewing gum can cause side effects. As many of the effects are due to nicotine, they can also occur when nicotine is obtained by smoking.
Effects related to smoking (nicotine withdrawal): The patient may experience unwanted effects because the patient have stopped smoking, or the patient have reduced the amount of nicotine being taken. These effects include: Dizziness, Headache, Irritability or aggression, Feeling low, Anxiety Restlessness, Poor concentration, Increased appetite or weight gain, Urge to smoke (craving), Sleeplessness or sleep disturbance, Lowering of heart rate.
Reported Side Effects: The commonly reported side-effect is diarrhoea.
Uncommonly reported side effects include fast heartbeat, burping, soreness of the tongue, oral mucosal blistering and exfoliation, prickling/tingling sensation of the mouth, body weakness, chest discomfort and pain, malaise, pain in jaw, abnormal dream, wheezing, voice disorder, shortness of breathing, nasal congestion, oropharyngeal pain, sneezing, throat tightness, increase sweating, skin itching, skin rash, hives, flushing and high blood pressure.
Rarely reported side effects include difficulty swallowing, mouth numbness and retching.
Undesirable effects arise from combination therapy (use of transdermal patch and another oral format together) may differ from monotherapy whereby the undesirable effects may be attributed to the pharmaceutical form. The frequency of the undesirable effects is comparable with what is given in the package insert for the respective product.
If the patient notice these or any other unwanted effects not listed in this package insert, tell a healthcare professional.