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Pharmacotherapeutic group: Drug used in nicotine dependence. ATC code: N07B A01.
Pharmacology: Pharmacodynamics: A sudden stop of smoking for long term smokers will experience the following withdrawal symptoms: urge or craving to smoke, dysphoria or depressed mood, insomnia, irritability, frustration or aggression, anxiety, difficulty in concentrating, restlessness or impatience, reduced heart rate, increased appetite or increase in weight.
Clinical studies have shown that nicotine replacement products can help smokers quit or reduce their smoking by helping these withdrawal symptoms.
Pharmacokinetics: Nicotine administered from a piece of nicotine chewing gum depends on the quantity of nicotine released into the oral cavity and readily absorbed through the oral mucosa. Maximum blood concentration is achieved after 30 minutes of chewing and is proportionate to the concentration 20-30 minutes after smoking a cigarette. The major eliminating organ is the liver. Greatly impaired kidney function is assumed to affect total clearance of nicotine.
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