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The effect of L-dopa may be reduced when vitamin B6 is administered concomitantly.
Pyridoxine-antagonists e.g. isoniazid (INH), cycloserin, penicillamin, hydralazine: The efficacy of vitamin B6 (pyridoxine) may be decreased.
Loop diuretics e.g. furosemide: In long-term use, the blood level of thiamine may be reduced.
Long term use of acid lowering agents may lead to Vitamin B12 deficiency.
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