Almost white shiny round coated tablets, highly convex on both sides.
Each coated tablet contains, as active ingredients, 100 mg vitamin B1 (thiamine disulfide), 200 mg vitamin B6 (pyridoxine hydrochloride) and 200 microgram vitamin B12 (cyanocobalamin).
Excipients/Inactive Ingredients: Montan-glycol wax, acacia, povidone, methyl cellulose, magnesium stearate, purified water, calcium carbonate, glycerol, mannitol, colloidal anhydrous silica, kaolin, gelatin, titanium dioxide (E 171), sodium starch glycolate, talc, sucrose.
NEUROBION is a combination of three essential neurotropic vitamins (B1, B6 and B12) in high dosage. Vitamins B1, B6 and B12 are of special importance for the metabolism in the peripheral and central nervous system. Their effect on the regeneration of nerves has been shown in various investigations using the vitamins individually and in combination.
Vitamin B1 plays an important role in major metabolic processes. Vitamin B6 has an analgesic effect. Vitamin B12 ensures blood cell formation and prevents degenerative processes of the nervous system. Both the individual function and the beneficial biochemical links between three vitamins justify their combined use.
NEUROBION is indicated for neurological and other disorders associated with disturbance of metabolic functions influenced by B-complex vitamins, including diabetic polyneuropathy, alcoholic peripheral neuritis and post-influenzal neuropathies.
NEUROBION is also recommended for the treatment of neuritis and neuralgia of the spinal nerves, especially facial paresis, cervical syndrome, low back pain, schialgia.
1 coated tablet three times daily to treat moderate cases, or to provide interval and follow-up therapy for a course of injections unless prescribed otherwise by the physician.
NEUROBION coated tablets are swallowed without chewing with a little liquid with or after meals.
The dosage and the duration of treatment are to be defined by the physician depending on the condition of the patient.
Sensorial neuropathy and other sensorial neuropathy syndromes which can be caused by long-term administration of high doses of pyridoxine improve gradually upon vitamin discontinuation.
NEUROBION must not be used in patients hypersensitive to any of the active ingredients or excipients of the product (see Description).
NEUROBION coated tablets are not suitable for the treatment of children below the age of 14 years due to the high content of active ingredients.
In the literature, neuropathies are described under long-term intake (6-12 months) of more than 50 mg mean daily dose of vitamin B6. Therefore, under long-term treatment, regular monitoring is recommended.
NEUROBION coated tablets contain sucrose; therefore, its use is not recommended in patients with intolerance to some sugars (i.e. rare hereditary galactose or fructose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, or sucrose-isomaltase insufficiency).
Effects on ability to drive and use machines: No effects of the product on the ability to drive or use machines are known.
No risks have become known associated with the use of NEUROBION during pregnancy at the recommended dosage.
Vitamins B1, B6 and B12 are secreted into human breast milk, but risks of overdose for the infant are not known. In individual cases, high doses of vitamin B6, i.e. >600 mg daily, may inhibit the production of breast milk.
Hypersensitivity reactions to vitamin B
1 such as sweating, tachycardia (rapid heart beat), and skin reactions with itching and urticaria are very rare.
Chromaturia ("reddish urine", appears during the first 8 hours after an administration and typically resolves within 48 hours) may occur.
Gastrointestinal complaints such as nausea, vomiting, diarrhoea or abdominal pain may occur.
Speak to a doctor, if such symptoms or other unwanted effects occur.
The effect of L-dopa may be reduced when vitamin B6 is administered concomitantly.
Pyridoxine-antagonists e.g. isoniazid (INH), cycloserin, penicillamin, hydralazine: The efficacy of vitamin B6 (pyridoxine) may be decreased.
Loop diuretics e.g. furosemide: In long-term use, the blood level of thiamine may be reduced.
Long term use of acid lowering agents may lead to Vitamin B12 deficiency.
Do not store above 25°C. Keep in a dry place.
A11DB - Vitamin B1 in combination with vitamin B6 and/or vitamin B12 ; Used as dietary supplements.
Neurobion coated tab
6 × 10's;50 × 10's
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