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Fertility: Fertility studies have not been performed.
Pregnancy: Animal studies have indicated that mivacurium has no adverse effect on foetal development.
There is no information on the use of MIVACRON in pregnant women therefore MIVACRON should not be used during pregnancy unless the expected clinical benefit to the mother outweighs any potential risk to the foetus.
Plasma cholinesterase levels decrease during pregnancy. MIVACRON injection has been used to maintain neuromuscular block during Caesarean section, but due to the reduced levels of plasma cholinesterase, dosage adjustments to the infusion rate were necessary. A further reduction in the infusion rate may also be required during Caesarean section in patients pre-treated with magnesium sulfate, due to the potentiating effects of magnesium. There has been no experience of MIVACRON multi-dose vials during Caesarean section.
Lactation: It is not known whether mivacurium is excreted in human milk.
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