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Symptoms and Signs: Prolonged muscle paralysis and its consequences are the main effects of overdosage with neuromuscular blocking agents. However, the risk of haemodynamic side effects, especially decreases in blood pressure may be increased.
Treatment: It is essential to maintain a patent airway together with assisted positive pressure ventilation until spontaneous respiration is adequate.
Full sedation will be required since consciousness is not impaired.
Recovery may be hastened by the administration of anticholinesterase agents accompanied by atropine or glycopyrrolate, once evidence of spontaneous recovery is present. Cardiovascular support may be provided by proper positioning of the patient and administration of fluids or vasopressor agents as required.
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