Metoperan Dosage/Direction for Use

The solution can be administered by the intravenous or intramuscular route. The intravenous doses must be administered as a slow bolus (for at least 3 minutes).
All indications (adults): A single 10 mg dose is recommended for the prevention of postoperative nausea and vomiting. The recommended dose for the symptomatic treatment of nausea and vomiting, including nausea and vomiting induced by migraine attacks and for the prevention of radiotherapy-induced nausea and vomiting is 10 mg per dose, 1 to 3 times daily. The maximum recommended daily dose is 30 mg or 0.5 mg/kg.
Treatment duration when administering by injection should be as short as possible and a switch to administration via oral or rectal route should be instituted as quickly as possible.
All indications (children from 1 to 18 years of age): The recommended dosage is 0.1 to 0.15 mg/kg, 1 to 3 times daily, by intravenous route. The maximum daily dose is 0.5 mg/kg. (See Table 1.)

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For the prevention of delayed chemotherapy-induced nausea and vomiting, the maximum treatment duration is 5 days.
For the prevention of postoperative nausea and vomiting, the maximum treatment duration is 48 hours.
Frequency of administration: A minimum interval of 6 hours between two administrations is to be respected, even if vomiting or rejection of the dose occurs.
Special populations: Elderly subjects: In elderly subjects, a dose reduction should be considered based on kidney and liver function and overall frailty.
Kidney failure: In patients with end-stage kidney failure (creatinine clearance 15 ml/min), the daily dose should be reduced by 75%. In patients with moderate to severe kidney failure (creatinine clearance between 15 and 60 ml/min), the dose should be reduced by 50%.
Liver failure: In patients with severe liver failure, the dose should be reduced by 50%. Other pharmaceutical forms may be more suitable for these patient populations.
Pediatric population: Metoclopramide is contraindicated in children aged less than one year.
Total daily dose of metoclopramide, especially for children and young adults, should not normally exceed 0.5 mg/kg body weight.
Route of Administration: The solution can be administered intravenously or intramuscularly.
Intravenous doses should be administered as a slow bolus (at least over 3 minutes).