M-M-R II Description

M-M-R II (Measles, Mumps, and Rubella Virus Vaccine Live) is a live virus vaccine for vaccination against measles (rubeola), mumps and rubella (German measles).
M-M-R II is a sterile lyophilized preparation of (1) ATTENUVAX (Measles Virus Vaccine Live, MSD), a more attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture; (2) MUMPSVAX (Mumps Virus Vaccine Live, MSD), the Jeryl Lynn (B level) strain of mumps virus propagated in chick embryo cell culture; and (3) MERUVAX II (Rubella Virus Vaccine Live, MSD), the Wistar RA 27/3 strain of live attenuated rubella virus propagated in WI-38 human diploid lung fibroblasts.
The reconstituted vaccine is for subcutaneous administration. "When reconstituted as directed, the dose for injection is 0.5 mL and contains not less than 1,000 CCID₅₀ (50% cell culture infectious dose) of measles virus; 12,500 CCID₅₀ of mumps virus; and 1,000 CCID₅₀ of rubella virus. Each dose of the vaccine is calculated to contain sorbitol (14.5 mg), sodium phosphate, sucrose (1.9 mg), hydrolyzed gelatin (14.5 mg), recombinant human albumin (≤ 0.3 mg), fetal bovine serum (<1 ppm), other buffer and media ingredients and approximately 25 mcg of neomycin." The product contains no preservative. Sorbitol and hydrolyzed gelatin are added as stabilizers.