Levophed Description

The drug product is comprised of a colorless or practically colorless liquid. The solution is colorless after dilution and not advised to be used if its color is pinkish or darker than slightly yellow or if it contains a precipitate.
LEVOPHED (norepinephrine bitartrate) injection, USP, contains the equivalent of 1 mg base of levophed per 1 mL (4 mg/4 mL).
Norepinephrine (sometimes referred to as l-arterenol/Levarterenol or l-norepinephrine) is a sympathomimetic amine which differs from epinephrine by the absence of a methyl group on the nitrogen atom.
LEVOPHED is (-)-α-(aminomethyl)-3,4-dihydroxybenzyl alcohol tartrate (1:1) (salt) monohydrate (molecular weight 337.3 g/mol).
LEVOPHED is supplied in a sterile aqueous solution in the form of the bitartrate salt to be administered by intravenous infusion. Norepinephrine is sparingly soluble in water, very slightly soluble in alcohol and ether, and readily soluble in acids. Each mL contains 1 mg of norepinephrine base (equivalent to 1.89 mg of norepinephrine bitartrate, anhydrous basis), sodium chloride for isotonicity, not more than 0.2 mg of sodium metabisulfite as an antioxidant. It has a pH of 3 to 4.5. The air in the vials has been displaced by nitrogen gas.
Excipients/Inactive Ingredients: Sodium Chloride, Sodium Metabisulfite, Water for Injection, Carbon Dioxide, Nitrogen.