Adults and Pediatrics 6 to 17 Years: Capsules: The capsules should be taken with liquid.
Acute diarrhea: the initial dose is 2 capsules (4mg) for adults and 1 capsule (2mg) for children; followed by 1 capsule (2mg) after every subsequent loose stool.
Chronic diarrhea: the initial dose is 2 capsules (4mg) daily for adults and 1 capsule (2mg) daily for children; this initial dose should be adjusted until 1-2 solid stools a day are obtained, which is usually achieved with a maintenance dose of 1-6 capsules (2mg-12mg) daily.
The maximum dose for acute and chronic diarrhea is 8 capsules (16mg) daily for adults; in children it must be related to the body weight (3 capsules/20kg) but should not exceed a maximum of 8 capsules per day.
Elderly: No dose adjustment is required for the elderly.
Renal Impairment No dose adjustment is required for patients with renal impairment.
Hepatic Impairment: Although no pharmacokinetic data are available in patients with hepatic impairment, Loperamide HCl should be used with caution in such patients because of reduced first pass metabolism. (See Warnings and Precautions.)