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Pharmacotherapeutic class: OSMOTIC LAXATIVE. ATC code: A06AD65.
Pharmacology: Pharmacodynamics: (A: digestive system and metabolism).
High molecular weight (4000) macrogols are long linear polymers on which water molecules are retained by hydrogen bonds. Following oral administration, they increase the volume of the intestinal fluids. The volume of non absorbed intestinal fluid is responsible for the laxative properties of the solution.
Pharmacokinetics: The electrolyte content of the powder is such that the reconstituted solution does not give rise to intestine/plasma electrolyte exchange. Pharmacokinetic findings confirm the absence of digestive absorption and bioconversion of macrogol 4000 after oral ingestion.
Toxicology: Preclinical safety data: Preclinical data from acute and repeated dose toxicity studies and genotoxicity studies performed with macrogol 4000 have not revealed any particular risk for humans. Due to the short duration of use of the product, no carcinogenicity studies have been performed.
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