Foliculin: Side Effects & Dosing

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Urofollitropin

Indications/Uses

Stimulation of follicular growth in infertile women, followed by hCG to induce ovulation for single follicular development eg, hypothalamic pituitary dysfunction (WHO group II), patients w/ polycystic ovarian disease & multiple follicular development (assisted conception techniques) eg, tubal occlusion, unexplained infertility, male factor infertility.

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Dosage/Direction for Use

Initially 75 IU SC daily for at least 7 days followed by hCG 5,000-10,000 IU 1 day after last dose. Duration: No >12 days. Evidence of ovulation w/ no pregnancy Repeat for at least ≥2 courses before increasing dose to 150 IU daily for 7-12 days. In vitro fertilization Initially 150 IU daily in early follicular phase (cycle day 2 or 3) until sufficient follicular development is attained. Duration: Not to exceed 10 days.

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Overdosage

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Contraindications

Hypersensitivity. High levels of FSH, primary ovarian failure; organic intracranial lesion eg, pituitary tumour; any cause of infertility other than anovulation; ovarian cysts or enlargement not due to ovarian polycystic disease; gynecological hemorrhages of unknown aetiology. Pregnancy.

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Special Precautions

Discontinue use if pelvic pain, abdominal distention, ovarian enlargement or oestrogen assays or ultrasound exam suggest excessive oestrogenic response. Ascites, pericardial effusion, hydrothorax, hemoconcentration, secondary hyperaldosteronism or hypercoagulability. Not to be given during pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Local inj site reactions, fever, arthralgias; GI symptoms eg, bloating, pelvic pain or sore breasts; mild to moderate ovarian enlargement, ovarian cysts.

Drug Interactions

Potentiated follicular response w/ clomifene citrate. Increased needed dosage w/ concurrent use of GnRH agonist.

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Storage

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Description

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Action

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MIMS Class

Trophic Hormones & Related Synthetic Drugs

ATC Classification

G03GA04 - urofollitropin ; Belongs to the class of gonadotropins. Used as ovulation stimulants.

Regulatory Classification

Presentation/Packing

Form

Foliculin powd for inj 75 IU

Packing/Price

1's

Form

Foliculin powd for inj 150 IU

Packing/Price

1's

Foliculin

urofollitropin

Manufacturer:

BSV Bioscience

Distributor:

Antah Pharma