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Long term overdosage may cause liver damage.
Overdosage with paracetamol if left untreated can result in severe, sometimes fatal liver damage and rarely, acute renal tubular necrosis. Skin rashes and hypersensitivity reactions may occur occasionally. CNS depressive effects include sedation and impaired performance (impaired driving performance, poor work performance, incoordination, reduced motor skills, and impaired information processing). Performance may be impaired in the absence of sedation and may persist till the morning after a night-time dose. CNS stimulatory effects of may include anxiety, hallucinations, appetite stimulation, muscle dyskinesis and activation of epilepthogenic factor.
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