Since nephrotoxic effects may be additive, the concurrent or sequential use of pentamidine isethionate with drugs having a nephrotoxic potential (e.g. aminoglycosides, amphotericin B, cisplatin, methoxyflurane or vancomycin) should be undertaken with caution. Pentamidine Isethionate for Injection should be administered with caution to patients who are receiving drugs with hepatotoxic potential or medication that can impair the haematopoietic system.