Pentamidine isethionate is indicated for intravenous administration in the treatment of the following conditions: As an alternative first line treatment for Pneumocystis carinii infection in AIDS patients; As second line treatment for Pneumocystis carinii infection in non-AIDS patients; As second line treatment of Leishmaniasis (visceral and cutaneous), except Leishmania aethiopica where it may be used as first line therapy; As second line treatment for Trypanosomiasis (except for the Trypanosomiasis rhodesiense strain due to lack of efficacy).