DBL Magnesium Sulfate Use In Pregnancy & Lactation

Effects on fertility: No data available.
Use in pregnancy: Magnesium sulfate heptahydrate is administered to pregnant women to treat seizures associated with severe pre-eclampsia and eclampsia. Magnesium sulfate heptahydrate readily crosses the placenta. Foetal serum concentrations approximate those of the mother. If magnesium sulfate heptahydrate is administered in the two hours preceding delivery, the neonate may be born with signs of hypermagnesaemia, including respiratory depression, and therefore DBL Magnesium Sulfate Concentrated Injection should not be given in the two hours preceding delivery unless it is the only therapy available to prevent or treat eclamptic seizures.
Bony abnormalities and congenital rickets have been reported in neonates born to mothers treated with parenteral magnesium sulfate heptahydrate for prolonged periods of time (5-7 days duration).
Use in lactation: After intravenous administration, magnesium is distributed into breast milk, and the concentration of magnesium in the breast milk is approximately twice that in the maternal serum. Magnesium salts should therefore be used with caution in lactating patients. However, magnesium is cleared from the breast milk within 24 hours of the cessation of the infusion.