DBL Magnesium Sulfate Dosage/Direction for Use

Magnesium sulfate heptahydrate is administered intravenously or intramuscularly.
Intravenous doses should be diluted to a concentration of 20% magnesium or less. For intravenous dosing, each 5 mL ampoule of DBL Magnesium Sulfate Concentrated Injection should be diluted by adding at least 7.5 mL of a compatible solution (see Compatibilities as follows).
For intramuscular dosing, a concentration of 25 to 50% is satisfactory for adults, while a concentration of 20% should be used for infants or children. For adult intramuscular administration dilution of DBL Magnesium Sulfate Concentrated Injection is not required, but each 5 mL ampoule could be diluted by adding up to 5 mL of a compatible solution.
The dose of magnesium should be adjusted according to the patients individual requirements and response.
The total adult daily dose should not exceed 30 to 40 g of magnesium sulfate heptahydrate per day.
Mild hypomagnesaemia: Adults: A dose of 1 g magnesium sulfate heptahydrate (8 mEq) intramuscularly every 6 hours for 4 doses is recommended.
Severe hypomagnesaemia: Adults: A dose of 0.25 g/kg magnesium sulfate heptahydrate intramuscularly over 4 hours is recommended. Alternatively a dose of 5 g may be given by slow intravenous infusion over 3 hours.
Total parenteral nutrition: Adults: A dose of 0.5 to 3.0 g magnesium sulfate heptahydrate (4 to 24 mEq) daily may be administered.
Infants: A dose of 0.25 to 1.25 g magnesium sulfate heptahydrate (2 to 10 mEq) daily may be administered.
Toxemia of pregnancy: An initial intravenous dose of 4 g magnesium sulfate heptahydrate is recommended. This is followed by an intramuscular dose of 4 to 5 g into each buttock. This may be followed by a dose of 4 to 5 g into alternate buttocks every four hours as needed.
Alternatively, the initial IV dose may be followed by an infusion of 1 to 2 g/hr.
Compatibilities: Magnesium sulfate heptahydrate is reported to be chemically stable and compatible with either sodium chloride 0.9%, lactated Ringer's injection, glucose 5% in water, or glucose 5% in sodium chloride 0.9%. It has been reported that at a concentration of 15 g/L, magnesium sulfate heptahydrate is chemically stable and compatible in all the infusion fluids listed previously for 48 hours and stored below 25°C. However, in order to reduce microbial contamination, the further diluted solutions should be prepared, stored and used within 24 hours.