Colfen Dosage/Direction for Use

For oral administration only.
The tablets need to be swallowed with a glass of liquid.
Adults: 10 mg once daily. A 5 mg starting dose may be proposed if this leads to satisfactory control of the symptoms.
Children: Children over 12 years of age: 10 mg once daily.
Children aged from 6 to 12 Years: 5 mg twice daily.
Elderly: Data do not suggest that the dose needs to be reduced in elderly subjects provided that the renal function is normal.
Patients with moderate to severe renal impairment: Since cetirizine is mainly excreted via renal route, in cases no alternative treatment can be used, the dosing intervals must be individualised according to renal function. Refer to the following table and adjust the dose as indicated. (See equation.)

Click on icon to see table/diagram/image

Dosing adjustments for adult patients with impaired renal function: See table.

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In paediatric patients suffering from renal impairment, the dose will have to be adjusted on an individual basis taking into account the renal clearance, age and body weight of the patient.
Patients with hepatic impairment: No dose adjustment is needed in patients with solely hepatic impairment.
Patients with hepatic impairment and renal impairment: Dose adjustment is recommended (see Patients with renal impairment as previously mentioned).