Pharmacology: Mechanism of Action: Cetirizine is an antihistamine as its principal effects are mediated via selective inhibition of peripheral H1 receptors.
Pharmacokinetics: Cetirizine is rapidly absorbed from the gastrointestinal tract after oral administration, peak plasma concentrations being attained in about 1 hour. It is highly bound to plasma proteins and has an elimination half-life of about 11 hours. Cetirizine has been detected in breast milk. It is excreted primarily in the urine mainly as unchanged drug.
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