Adaxil Special Precautions

Special Warnings: In the absence of studies on reproductive function in humans, the use of ADAXIL during pregnancy and lactation should be avoided.
No important effects on the central nervous system or motor system are known that might impair the ability to drive or use machines. However, caution is adviced if somnolence or visual disturbances are experienced.
The colouring agent Sunset yellow (E110) may cause allergic reactions.
Precautions for Use: ADAXIL is not indicated for the treatment of acute painful symptoms.
Glucosamine is derived from seafood.
This medicinal product contains sodium. To be taken into consideration by patients on a controlled sodium diet.
In patients with cardiac and/or renal insufficiency, edema and water retention was observed very rarely. This effect could be attributed to the effect of chondroitin sulphate. The administration of ADAXIL to these patients should be under strict medical supervision.
No special studies were performed in patients with hepatic insufficiency. The administration of ADAXIL to patients with severe hepatic insufficiency should be under strict medical supervision.
Caution is advised in treatment of patients with impaired glucose tolerance. Closer monitoring of blood sugar levels may be necessary at the beginning of treatment.
An increased effect of coumarinic anticoagulants (such as warfarin) during concomitant treatment with glucosamine sulphate, one of the active ingredients of ADAXIL, may occur. Therefore, a closer monitoring of the coagulation parameters may be considered in those patients being treated with ADAXIL.
Due to its chondroitin sulphate content, in case of concomitant administration of platelet anti-aggregant drugs such as acetylsalicylic acid, dipyridamol, clopidogrel, ditazol, trifusal and ticlopidine, ADAXIL should be administered under strict medical supervision.
Concurrent treatment with glucosamine sulphate may increase the gastrointestinal absorption of tetracyclines. Caution is advised in case of concomitant administration of ADAXIL and tetracyclines.