Xigduo XR Dosage/Direction for Use

Recommended Dosing: Healthcare providers should individualize the starting dose of XIGDUO XR based on the patient's current treatment. [See Presentation.]
XIGDUO XR should generally be taken orally, once daily with the evening meal.
XIGDUO XR tablets must be swallowed whole and never crushed, cut, or chewed. Occasionally, the inactive ingredients of XIGDUO XR will be eliminated in the feces as a soft, hydrated mass that may resemble the original tablet.
Dosing may be adjusted based on effectiveness and tolerability while not exceeding the maximum recommended daily dose of 10 mg dapagliflozin and 2000 mg metformin HCl.
Patients with Renal Impairment: No dosage adjustment for XIGDUO XR is indicated in patients with an eGFR greater than or equal to 45 mL/min/1.73m².
Assessment of renal function is recommended prior to initiation of XIGDUO XR therapy and periodically thereafter.
XIGDUO XR is not recommended in patients with an eGFR below 45 mL/min/1.73 m².
XIGDUO XR is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m² [see Contraindications, Precautions, Adverse Reactions, and Use in Specific Populations].
Hepatic Impairment: This medicinal product must not be used in patients with hepatic impairment.
Discontinuation for Iodinated Contrast Imaging Procedures: Xigduo XR at the time of, or prior to, an iodinated contrast imaging procedure in patients with a history of liver disease, alcoholism or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Re-evaluate eGFR 48 hours after the imaging procedure; restart Xigduo XR if renal function is stable (see Precautions).