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Adults and Children >12 years: 1-2 g once daily (every 24 hrs). Infants and Children (3 weeks to 12 years): 20-80 mg/kg body weight/day. Neonates: 20-50 mg/kg body weight once daily.
No dose adjustments are necessary in patients with renal or liver dysfunctions. However, concentration of ceftriaxone in blood should be monitored in patients with severe renal impairment (ie, dialysis patients) and patients with both hepatic and renal impairment.
Administration: IM Injection: Dissolve 1 g ceftriaxone with 3.6 mL of 1% lidocaine sterile solution. After reconstitution, each mL contains 250 mg ceftriaxone.
IV Injection: Dissolve 1 g ceftriaxone with 10 mL water for injection. After reconstitution, each mL of solution contains 100 mg ceftriaxone.
