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L-dopa: The effect of L-dopa may be reduced when Pyridoxine HCl is administered concomitantly.
Pyridoxine HCl-antagonists, e.g. lsoniazid (INH), Cycloserine, Penicillamine, Hydralazine: The efficacy of Pyridoxine HCl may be decreased.
Loop diuretics, e.g. Furosemide: In long-term use, the blood level of Thiamine HCl may be reduced.
