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Pharmacology: Mode of Action: Nystatin is fungistatic and fungicidal in vitro against a variety of yeasts and yeast-like fungi. Nystatin acts by binding to sterols in the cell membrane of susceptible Candida sp. resulting in a change in membrane permeability and the subsequent leakage of intracellular components.
On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. Nystatin exhibits no activity against bacteria, protozoa or viruses.
Pharmacokinetics: Gastrointestinal absorption of nystatin is insignificant. Most orally administered nystatin is passed unchanged in the stool.
