Uncomplicated UTI caused by E. coli & Proteus mirabilis; otitis media caused by H. influenzae (+ve & -ve strain of β-lactamase), Moraxella catarrhalis & Strep pyogenes; pharyngitis & tonsillitis caused by S. pyogenes; acute bronchitis & acute exacerbation of chronic bronchitis caused by S. pyogenes, S. pneumoniae & H. influenzae; typhoid fever in paed patients w/ multi-resistant to standard treatment; uncomplicated gonorrhoeae caused by N. gonorrhoeae.
Typhoid fever in childn10-15 mg/kg daily for 2 wk.Patient w/ CrCl 21-60 mL/min or undergoing haemodialysis75% of standard dose, CrCl <20 mL/min or patient undergoing continuous ambulatory peritoneal dialysis (CAPD)50% of standard dose. CapAdult & childn >30 kg 50-100 mg twice daily. May be increased to 200 mg twice daily in severe infections. Uncomplicated gonorrhea 400 mg as a single dose. Dry susp/oral drops Childn 1.5-3 mg/kg in 2 divided doses. May be increased to 6 mg/kg in 2 divided doses.
Shock, hypersensitivity (ie, skin rash, urticaria, erythema, pruritus or fever), granulocytopenia, eosinophilia, thrombocytopenia; increased ALT/AST/alkaline phosphatase; acute kidney insufficiency; pseudomembranous colitis, vomiting, diarrhea, abdominal discomfort, abdominal pain, anorexia, nausea, flatulence, constipation; pulmonary interstitial emphysema (PIE syndrome); stomatitis, candidiasis; vit K or vit B deficiencies; headache, dizziness; may result in false +ve of urine glucose level using Benedict or Fehling soln, or Clinitest; may cause +ve result in Direct Coombs test.
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