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Bisoprolol: Overt Cardiac Failure: In general, β-blocking agents should be avoided in patients with overt congestive failure. However, in some patients with compensated cardiac failure, it may be necessary to utilize these agents. In such patients, they must be used cautiously. Cardiogenic shock, sick sinus syndrome, sinoatrial block, 2nd- or 3rd-degree atrioventricular block, considerable bradycardia (pulse slower than 50 beats/min), asthma and chronic obstructive bronchopneumopathies in their severe forms, untreated pheochromocytoma, Raynaud's disease and peripheral arterial disorders in their severe forms, hypotension, known hypersensitivity to bisoprolol and metabolic acidosis. Acute myocardial infarction, prinzmetal's angina.
Hydrochlorothiazide: Known hypersensitivity to hydrochlorothiazide or other sulfonamide derivatives, renal failure (CrCl <30 mL/min), coma and pre-coma hepaticum, severe hypokalemia or hyponatremia.
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