Lodoz Mechanism of Action

Pharmacotherapeutic Group: Selective β₁-adrenoreceptor blocker and diuretic.
Pharmacology: Mode of Action: Clinical studies have demonstrated synergy for the β-blocker/diuretic combination and its efficacy at ¼ of the standard doses (5 mg/6.25 mg) in the treatment of mild to moderate hypertension.
The pharmacodynamic effects eg, hypokalemia (hydrochlorothiazide) and bradycardia, asthenia and headache (bisoprolol) are dose-dependent. The combination of the 2 active substances at ¼ of the usual doses (5 mg/6.25 mg) aims to reduce these effects.
Bisoprolol is a highly selective β₁-adrenoreceptor inhibitor, devoid of intrinsic sympathomimetic activity or significant membrane-stabilizing effects. As for other β₁-receptor antagonists, the mode of action of bisoprolol in hypertension is not well understood, but it has been shown that the substance distinctly lowers serum renin and slows down the heart rate.
Hydrochlorothiazide is a thiazide diuretic with antihypertensive activity. Its diuretic effect is due to inhibition of the active transport of Na⁺ from renal tubules into blood, preventing reabsorption of Na⁺.