May increase serum levels of digoxin. Reduction of insulin dose or antidiabetic drugs may be needed. May prolong QT interval & increase risk of ventricular arrhythmias with drugs that have the potential to induce cardiac arrhythmias eg, mefloquine. Antiepileptic drug activity may be disrupted. May increase side effects with methotrexate. Increased levels of cyclosporine.
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