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Etoricoxib is administered orally. Etoricoxib may be taken with or without food. Etoricoxib should be administrated for the shortest duration possible and the lowest effective daily dose.
Osteoarthritis: The recommended dose is 60 mg once daily.
Chronic musculoskeletal pain: The recommended dose is 60 mg once daily.
Acute Gouty Arthritis: The recommended dose is 120 mg once daily. Etoricoxib should be used only for the acute symptomatic period limited to a maximum of 8 days.
Acute pain associated with dental surgery: The recommended dose is 90 mg once daily.
Doses greater than those recommended for each indication have either not demonstrated additional efficacy or have not been studied. Therefore, the dose for each indication is the maximum recommended dose.
Elderly, gender, race: No dosage adjustment in etoricoxib is necessary for the elderly or based on gender or race.
Hepatic insufficiency: In patient with mild hepatic insufficiency (Child-Pugh score 5-6), a dose of 60 mg once daily should not be exceeded. In patients with moderate hepatic insufficiency (Child-Pugh score 7-9), the dose should be reduced: a dose of 60 mg every other day should not be exceeded, administration of 30 mg once daily can also be considered. There are no clinical or pharmacokinetic data in patients with severe hepatic insufficiency (Child-Pugh score >9) (see PRECAUTIONS).
Renal insufficiency: In patients with advanced renal disease (creatinine clearance <30 ml/min), treatment with etoricoxib is not recommended. No dosage adjustment is necessary for patients with lesser degrees of renal insufficiency (creatinine clearance ≥30 ml/min) (see PRECAUTIONS).
