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Paracetamol should be used with caution in cases of: Hepatocellular insufficiency; Severe renal insufficiency (creatinine clearance ≤30 ml/min); Chronic alcoholism; Chronic malnutrition (low reserves of hepatic glutathione); Dehydration.
Use in pregnancy: Paracetamol should only be used during pregnancy after a carefully benefit-risk assessment. In this case, the recommended posology and duration must be strictly observed.
Use in lactation: After oral administration, Paracetamol is excreted into breast milk in small quantities. No undesirable effects on nursing infants have been reported. Consequently, Paracetamol may be used in breast-feeding women.
