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Community-acquired pneumonia
Adult: 500 mg once daily for at least 2 consecutive days, followed by oral azithromycin doses to complete 7-10 days of therapy. IV doses are given via infusion over 1 hour (for 2 mg/mL concentration) or over 3 hours (for 1 mg/mL concentration). Timing of transition to oral therapy must be individualised according to the patient's clinical response.
Intravenous
Pelvic inflammatory disease
Adult: 500 mg once daily for 1-2 days, followed by oral azithromycin doses to complete 7 days of therapy. IV doses are given via infusion over 1 hour (for 2 mg/mL concentration) or over 3 hours (for 1 mg/mL concentration). Timing of transition to oral therapy must be individualised according to the patient's clinical response.
Ophthalmic
Trachomatous conjunctivitis
Adult: As 1.5% eye drop solution: Instil 1 drop into the affected eye(s) bid for 3 days. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As 1.5% eye drop solution: Same as adult dose. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As 1.5% eye drop solution: Same as adult dose. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Ophthalmic
Bacterial conjunctivitis
Adult: As 1% eye drop solution: Instil 1 drop into the affected eye(s) bid (8-12 hours apart) for the 1st 2 days, then instil 1 drop once daily for the next 5 days. As 1.5% eye drop solution: Instil 1 drop into the affected eye(s) bid for 3 days. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As 1.5% eye drop solution: Same as adult dose. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As 1.5% eye drop solution: Same as adult dose. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Uncomplicated gonorrhoea
Adult: 1 g or 2 g as a single dose. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Prophylaxis of disseminated Mycobacterium avium complex (MAC) infections
Adult: Alone or in combination with rifabutin in patients with advanced HIV infection: 1.2 g once weekly. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Pelvic inflammatory disease
Adult: Following IV therapy: 250 mg once daily to complete 7 days of therapy.
Oral
Acute otitis media
Adult: 500 mg once daily for 3 days. Alternatively, 500 mg as a single dose on day 1, followed by 250 mg once daily on days 2-5. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: ≥6 months As oral susp: 30 mg/kg as a single dose or 10 mg/kg once daily for 3 days. Alternatively, 10 mg/kg as a single dose on day 1, followed by 5 mg/kg once daily on days 2-5. For patients weighing >45 kg: Same as adult dose. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: ≥6 months As oral susp: 30 mg/kg as a single dose or 10 mg/kg once daily for 3 days. Alternatively, 10 mg/kg as a single dose on day 1, followed by 5 mg/kg once daily on days 2-5. For patients weighing >45 kg: Same as adult dose. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Pharyngitis, Tonsillitis
Adult: 500 mg once daily for 3 days. Alternatively, 500 mg as a single dose on day 1, followed by 250 mg once daily on days 2-5. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: ≥2 years As oral susp: 12 mg/kg once daily for 5 days. Alternatively, 20 mg/kg once daily for 3 days. Max: 500 mg daily. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: ≥2 years As oral susp: 12 mg/kg once daily for 5 days. Alternatively, 20 mg/kg once daily for 3 days. Max: 500 mg daily. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Chancroid, Uncomplicated genital infections due to Chlamydia trachomatis
Adult: 1 g as a single dose. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Skin and soft tissue infections
Adult: 500 mg once daily for 3 days. Alternatively, 500 mg as a single dose on day 1, followed by 250 mg once daily on days 2-5. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As oral susp: 10 mg/kg once daily for 3 days. Alternatively, 10 mg/kg as a single dose on day 1, followed by 5 mg/kg once daily on days 2-5. For patients weighing >45 kg: Same as adult dose. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As oral susp: 10 mg/kg once daily for 3 days. Alternatively, 10 mg/kg as a single dose on day 1, followed by 5 mg/kg once daily on days 2-5. For patients weighing >45 kg: Same as adult dose. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Community-acquired pneumonia
Adult: 500 mg once daily for 3 days. Alternatively, 500 mg as a single dose on day 1, followed by 250 mg once daily on days 2-5. Following IV therapy: 500 mg once daily to complete 7-10 days of therapy. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: ≥6 months As oral susp: 10 mg/kg (Max: 500 mg) as a single dose on day 1, followed by 5 mg/kg once daily on days 2-5 (Max: 250 mg daily). Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: ≥6 months As oral susp: 10 mg/kg (Max: 500 mg) as a single dose on day 1, followed by 5 mg/kg once daily on days 2-5 (Max: 250 mg daily). Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Acute bacterial sinusitis
Adult: 500 mg once daily for 3 days. Alternatively, 500 mg as a single dose on day 1, followed by 250 mg once daily on days 2-5. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: ≥6 months As oral susp: 10 mg/kg once daily for 3 days. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: ≥6 months As oral susp: 10 mg/kg once daily for 3 days. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Acute bacterial exacerbation of chronic bronchitis
Adult: 500 mg once daily for 3 days. Alternatively, 500 mg as a single dose on day 1, followed by 250 mg once daily on days 2-5. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
