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Pregnancy: For Glimepiride: This drug must not be taken during pregnancy. Otherwise there is risk of harm to the child. Pregnant patient or the patient planning a pregnancy must inform their physician. It is recommended that such patients change over to insulin.
For Metformin: A limited amount of data from the use of metformin in pregnant women does not indicate an increased risk of congenital abnormalities. Animal studies do not indicate harmful effects with respect to pregnancy, embryonal or fetal development, parturition or postnatal development.
However, when the patient plans to become pregnant and during pregnancy, it is recommended that diabetes is not treated with metformin but insulin should be used to maintain blood glucose levels as close to normal as possible.
Lactation: For Glimepiride: To prevent possible ingestion with the breast milk and possible harm to the child, glimepiride must not be taken by breast-feeding women. If necessary the patient must change over to insulin, or must stop breast-feeding.
For Metformin: Metformin is excreted into milk in lactating rats.
Metformin is excreted into human breast milk. No adverse effects were observed in breastfed newborns/infants. However, as only limited data are available, breastfeeding is not recommended during metformin treatment. A decision should be made on whether to discontinue nursing or to discontinue metformin, taking into account the benefit and potential risk of adverse effect on the child and importance of the compound to the mother.
