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The dosage of anti-diabetic drugs should be individualized based on the patient's blood glucose levels. Generally, it should be recommended to initiate the lowest effective dose and increase the dose depending on the patient's blood glucose levels. Adequate monitoring of blood glucose levels should be performed for this. It should be administered once or twice per day before or with the meals. When switching from combination therapy of glimepiride plus metformin as separate tablets, AMARYL M should be administered on the basis of dosage currently being taken.