Vincristine Sulphate Pharmachemie Caution For Usage

Special precautions for disposal and other handling: Inspection prior to use: Only clear solutions without particles should be used. The product should not be used in case of a defective container.
Handling and disposal: Injectable solutions of cytotoxic drugs should be prepared by specialized trained personnel who are familiar with the drugs used, under conditions that guarantee environmental protection and especially protection of personnel handling the drugs. Vincristine should not be used by pregnant staff.
Any contact with the liquid should be avoided. The solutions should be prepared in a special area in which smoking, eating and drinking are prohibited. During the preparation a strictly aseptical work technique must be applied; as protective measures the use of gloves, mouth mask, safety goggles and protective clothing are needed. The use of a LAF-cabinet with vertical flow direction is recommended. During administration gloves should be worn. With waste processing, the nature of this product should be taken into account.
If the solution does get in contact with the skin, mucous membranes or eyes, immediate excessive flushing with water should occur.
Extravasation should be avoided. Should extravasation occur, the injection should be stopped immediately and the possibly remaining dose should be injected in a different vein. Local injection of hyaluronidase 250 1U/mL (1 mL subcutaneous around the lesion) and moderate heat application at the site where the extravasation occurred, can help disperse the product and the limit the discomfort and possible cellulitis to a minimum. In the unit where vincristine sulphate is administered, the hospital's cytostatics extravasation set of the hospital should be available.
Excreta and vomitus should be handled with caution.
Broken containers should be handled with the same precautions and treated as contaminated waste. Contaminated waste should be disposed of by incineration in rigid, appropriately labelled containers.
Incompatibilities: In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.