Truvada Dosage/Direction for Use

Truvada should be initiated by a physician experienced in the management of HIV infection.
Posology: Treatment of HIV in adults and adolescents aged 12 years and older, weighing at least 35 kg: One tablet, once daily.
Prevention of HIV in adults and adolescents aged 12 years and older, weighing at least 35 kg: One tablet, once daily.
Separate preparations of emtricitabine and tenofovir disoproxil are available for treatment of HIV-1 infection if it becomes necessary to discontinue or modify the dose of one of the components of Truvada. Please refer to the Summary of Product Characteristics for these medicinal products.
If a dose of Truvada is missed within 12 hours of the time it is usually taken, Truvada should be taken as soon as possible and the normal dosing schedule should be resumed. If a dose of Truvada is missed by more than 12 hours and it is almost time for the next dose, the missed dose should not be taken and the usual dosing schedule should be resumed.
If vomiting occurs within 1 hour of taking Truvada, another tablet should be taken. If vomiting occurs more than 1 hour after taking Truvada a second dose should not be taken.
Special populations: Elderly: No dose adjustment is required (see Pharmacology: Pharmacokinetics under Actions).
Renal impairment: Emtricitabine and tenofovir are eliminated by renal excretion and the exposure to emtricitabine and tenofovir increases in individuals with renal dysfunction (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Adults with renal impairment: Truvada should only be used in individuals with creatinine clearance (CrCl) < 80 mL/min if the potential benefits are considered to outweigh the potential risks. (See Table 8.)

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Paediatrics with renal impairment: Not recommended for use in individuals under the age of 18 years with renal impairment (see Precautions).
Hepatic impairment: No dose adjustment is required in patients with hepatic impairment (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Paediatric population: The safety and efficacy of Truvada in children under the age of 12 years have not been established (see Pharmacology: Pharmacokinetics under Actions).
Method of administration: Oral administration. It is preferable that Truvada is taken with food.
The film-coated tablet can be disintegrated in approximately 100 mL of water, orange juice or grape juice and taken immediately.