Takhzyro Patient Counseling Information

Instructions for use: STEP 1: Prepare for your injection: a. Gather an alcohol swab, cotton ball/gauze pad, adhesive bandage and a sharps disposal container and place on a clean, flat, surface in a well-lit area. These supplies are not included in the TAKHZYRO packaging.
b. Remove TAKHZYRO from refrigerator, open the carton box and remove the TAKHZYRO pre-filled syringe from the tray.
Do not use the TAKHZYRO pre-filled syringe if the tamper evident seal is open or broken.
Before you prepare your injection, allow the pre-filled syringe to reach room temperature for at least 15 to 30 minutes.
Your medicine is sensitive to warm temperatures. Do not use external heat sources such as hot water to warm your TAKHZYRO pre-filled syringe.
Do not remove the needle cap until you are ready to inject.
c. Wash your hands with soap and water. Dry your hands completely.
d. Check the expiration date on the label.
Do not use TAKHZYRO pre-filled syringe if the expiration date has passed.
e. Visually inspect the TAKHZYRO pre-filled syringe for any damage and make sure the medicine is colourless to slightly yellow.
Do not use product if syringe is damaged - e.g., cracked syringe.
Do not administer if the medicine is discoloured, cloudy or has flakes or particles in it and call your Healthcare Provider.
You might see air bubbles in the TAKHZYRO pre-filled syringe. This is normal and will not affect your dose.
STEP 2: Select and prepare your injection site: a. The TAKHZYRO pre-filled syringe should be injected into your stomach (abdomen), thigh, or the back of the upper arm (the outer area of the upper arm is not recommended if you are injecting yourself).
It is important to rotate injection sites to keep skin healthy. Each new injection should be given at least 3 cm from the last site you used.
Do not inject into an area of your body where the skin is irritated, reddened, bruised, or infected.
The area you choose for injection should be at least 5 cm away from any scars or your belly button (navel).
b. Clean the injection site with an alcohol swab and allow it to dry.
Do not fan or blow on the clean site.
Do not touch this area again before giving your injection.
c. Remove needle cap from the TAKHZYRO pre-filled syringe. Gently pull the needle cap straight off with one hand and firmly hold the middle of the TAKHZYRO pre-filled syringe with the other hand. Throw away the needle cap.
Do not recap your TAKHZYRO pre-filled syringe.
Do not use the TAKHZYRO pre-filled syringe if it has been dropped without the needle cap on or if the needle looks damaged or bent.
Do not touch the needle or allow the needle to touch anything.
STEP 3: Inject TAKHZYRO: a. Grip the TAKHZYRO pre-filled syringe in one hand like a pencil. Avoid touching the needle or pushing on the plunger.
b. With your other hand, gently pinch about 3 cm fold of skin at the cleaned injection site.
c. With one quick, short motion, push needle all the way into skin. Make sure to keep the needle in place.
d. Slowly push the plunger until all of the liquid is injected and the syringe is empty, then gently let go of your skin.
e. Slowly withdraw needle while maintaining the syringe at the same angle.
f. Press cotton ball or gauze pad over injection site if needed and hold for 10 seconds.
Do not rub the injection site. You may have a minor bleeding. This is normal.
Cover injection site with an adhesive bandage if needed.
g. Throw away your used TAKHZYRO pre-filled syringe.
Do not touch the needle.
To avoid a needle-stick injury, do not recap the needle.
Put your used TAKHZYRO pre-filled syringes in a sharps disposal container right away after use.
Do not reuse the TAKHZYRO pre-filled syringe and any of your injection supplies.