SC Initially 300 mg every 2 wk. Consider dose reduction of 300 mg every 4 wk in patients who are stably attack-free on treatment, especially those w/ low wt.
Discontinue immediately & initiate appropriate treatment in case of a severe hypersensitivity reaction. Not intended for treatment of acute HAE attacks. Interference w/ activated partial thromboplastin time assay. Preferable to avoid during pregnancy. Lactation. Safety & efficacy have not been established in childn <12 yr.
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