Famotidine is a competitive inhibitor of histamine H2-receptors. It inhibits gastric secretion, that is both the acid concentration and volume of basal and stimulated gastric secretion suppresses, while changes in pepsin secretion are proportional volume output.
Indications/Uses
It is indicated in: 1) Short-term treatment of active duodenal ulcer.
2) Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer.
3) Short-term treatment of active benign gastric ulcer.
4) Short-term treatment of gastroesophageal reflux disease (GERD).
5) Treatment of pathological hypersecretory conditions (eg. Zollinger-Ellison syndrome, multiple endocrine adenomas).
Dosage/Direction for Use
Oral administration. Adult: Active duodenal and active benign gastric benign ulcer: 40mg daily at bedtime for 4-8 weeks.
Maintenance therapy for duodenal ulcer: 20mg once a day at bedtime.
Gastro-oesophageal reflux disease (GERD): Initial dose is 20mg to 40mg twice daily for 6 to 12 weeks.
Pathological hypersecretory conditions: Initial: 20mg every 6 hours. In some patients, a higher starting dose may be required. Doses should be adjusted to individual patient needs and should continue as long as indicated. Doses up to 160mg every 6 hours have been administered to some adult patients with severe Zollinger-Ellison Syndrome.
Contraindications
It is contraindicated to patients with known hypersensitivity to Famotidine.
Special Precautions
Famotidine is known to be excreted in kidney, dosage adjustment should be considered for patients with moderate or severe renal impairments and for elderly patients who are more likely to have decreased renal function.
Use In Pregnancy & Lactation
Famotidine should not be used during pregnancy unless the potential benefits outweigh the potential risks to the foetus.
Concurrent administration of famotidine and antacid may result in a decrease in the bioavailability of famotidine.
Probenecid has been reported to inhibit renal tubular secretion of famotidine.
Caution For Usage
Incompatibilities: No incompatibilities known.
Storage
Store in airtight containers, in a cool dry place below 30°C.
A02BA03 - famotidine ; Belongs to the class of H2-receptor antagonists. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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