Stadovas 5/Stadovas 10 Drug Interactions

Amlodipine has been safely administered with thiazide diuretics, alpha blockers, beta-blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual glyceryl trinitrate, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycaemic drugs.
Effect of other agents on amlodipine: Cimetidine, grapefruit juice, antacid: Co-administration of amlodipine and those had no significant effect on the pharmacokinetics of amlodipine.
Sildenafil: When amlodipine and sildenafil were used in combination, each agent independently exerted its own blood pressure lowering effect.
Effect of amlodipine on other agents: Atorvastatin, ethanol (alcohol): Co-administration of amlodipine with 80 mg atorvastatin or ethanol resulted in no significant change in the steady-state pharmacokinetics parameters of atorvastatin or ethanol.
Digoxin: Co-administration of amlodipine with digoxin did not change serum digoxin levels or digoxin renal clearance.
Warfarin: Co-administration of amlodipine with warfarin did not change the warfarin prothrombin response time.
Cyclosporine: Pharmacokinetics studies with cyclosporine have demonstrated that amlodipine does not significantly alter the pharmacokinetics of cyclosporine.