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Pregnancy: It is preferable to maintain a good psychological balance throughout pregnancy. If medical treatment is necessary to ensure this balance, treatment should be initiated or continued at an effective dose throughout pregnancy and if possible as monotherapy.
Animal data is reassuring but clinical data is still insufficient. In consideration of this data, it is preferable not to use tianeptine during pregnancy whatever the term. If initiation or continuation of treatment by tianeptine proves to be vital during pregnancy, the pharmacological profile of the molecule should be taken into account when monitoring the newborn baby.
Breast-feeding: Tricyclic antidepressants are excreted into breast milk, and thus breast-feeding is not recommended during treatment.
Fertility: A study demonstrated in rats a decrease in reproductive performance in females (increase in pre-implantation losses) at a maternotoxic dose. The clinical impact is unknown.
