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Few cases of overdosage with irbesartan have been reported, with no complaints and no significant clinical sequelae. Reported overdoses ranged from 600 - 900 mg daily. Durations of overdosing ranged from 2 - 3 weeks up to 30 days and over. Experience in adults exposed to doses of up to 900 mg/day for 8 weeks revealed no toxicity.
The most likely manifestations of overdosage are hypotension and tachycardia; bradycardia might also occur.
No specific information is available on the treatment of overdosage with irbesartan. The patient should be closely monitored, and the treatment should be supportive and relieve symptoms. Suggested measures include induction of emesis and/or gastric lavage. Activated charcoal may be useful in the treatment of overdosage.
Irbesartan is not removed by hemodialysis.
For management of a suspected drug overdose, contact the regional poison control centre.
